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Scientific Studies on Beta Glucan
Abbreviations:
BG
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Beta Glucan
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UTRI
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Upper Respiratory Tract Infection
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DHA
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Docosahexaenoic acid- omega 3 fatty acid
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Allergy
Research
Title | Summary | Link | Authors | Year |
Cow’s Milk-Based Beverage Consumption in 1- to 4-Year-Olds and Allergic Manifestations | Group of children were given placebo or cows milk-based beverage containing Beta-glucan, DHA, prebiotics & GOS. The BG group had fewer episodes of allergic manifestations like wheezing, allergic cough & eczema compared to control group. |
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M. V. Pontes, T. C. M. Ribeiro, H. Ribeiro, A. P. de Mattos, I. R. Almeida, V. M. Leal, G. N. Cabral, S. Stolz, W. Zhuang, and D. M. F. Scalabrin | 2016 |
ß-Glucan Supplementation, Allergy Symptoms and Quality of Life in Self-Described Ragweed Allergy Sufferers. | Ragweed is a common weed in North America. Group of adults who suffer from ragweed allergy were given placebo or 250mg yeast beta glucan (the equivalent of 1 can of Mude) daily for 4 weeks. Supplementation with BG for 4 weeks improved allergy symptoms, overall physical health, and emotional well-being compared with placebo in the ragweed allergy sufferers. | View | Shawn M Talbott, Julie A Talbott, Tracy L Talbott, and Elaine Dingler | 2014 |
Reviews
Title | Summary | Link | Authors | Year |
Beta-glucans in higher fungi and their health effects | Beta Glucans may protect against allergic reactions by optimising the balance of white blood cells in the body. | View | Otakar Rop, Jiri Mlcek, Tunde Jurikova | 2009 |
Effects of orally administered yeast‐derived beta‐glucans: A review | Yeast beta glucan supplementation showed positive effects against seasonal pollen allergies and may be beneficial alongside allergy medication. | View | Anne Berit C. Samuelsen, Jürgen Schrezenmeir, Svein H. Knutsen | 2013 |
Antioxidant
Study highlights that beta glucans exhibit antioxidant properties.
Reviews
Title | Summary | Link | Authors | Year |
Nutraceutical functions of beta-glucans in human nutrition | Beta Glucans exhibit high antioxidant properties, which may reduce the risk of diseases including atherosclerosis, diabetes and cancer. | View | Anna Ciecierska, Małgorzata Ewa Drywień, Jadwiga Hamulka, Tomasz Sadkowski | 2019 |
Cognitive
Study highlights that beta glucans exhibit properties which could help in Alzheimers disease.
Research
Title | Summary | Link | Authors | Year |
Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1–42-induced AD-like mice | Inflammation, insulin resistance and changes to the gut microbiota are suggested precursors to Alzheimer's Disease. In this study, supplemention of mice with yeast beta gluten improved brain insulin resistance and neuroinflammation, as well as increasing the "good bacteria" in the gut, and thus, could offer potential in the early stages of Alzheimer's disease. | View | Mengdai Xu, Xiaoxing Mo, Hao Huang, Xi Chen, Hongjie Liu, Zhao Peng, Liangkai Chen, Shuang Rong, Wei Yang, Shufang Xu, Liegang Li | 2020 |
Digestion
Studies highlight that beta glucans aid in digestion, promoting good bacteria in the gut-reducing constipation & aiding digestion.
Reviews
Title | Summary | Link | Authors | Year |
Nutraceutical functions of beta-glucans in human nutrition | Beta Glucans are a prebiotic and can aid in prompting the proper functioning of the GI tract. This may prevent inflammation and disease of the digestive system, such as colon cancer. | View | Anna Ciecierska, Małgorzata Ewa Drywień, Jadwiga Hamulka, Tomasz Sadkowski | 2019 |
Beta Glucan: A Valuable Functional Ingredient in Foods | Beta glucans can aid in reducing glycaemic index, promoting good bacteria in the gut, reducing constipation and aiding digesiton. | View | Asif Ahmad, Faqir Muhammad Anjum, Tahir Zahoor, Haq Nawaz & Syed Muhammad Raihan Dilshad | 2012 |
Immunity - Common Cold
Studies below highlight that yeast beta glucan can have beneficial effects in reducing the severity, duration & incidence of the common cold in subjects.
Research
Title | Summary | Link | Authors | Year |
Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects | Adults were given placebo or 900mg of yeast beta glucan (the equivalent of 3.6 cans of Mude). In the test group, supplementation with yeast BG reduced the number of common cold infections by 25 % as compared to placebo. | View | Annegret Auinger, Linda Riede, Gordana Bothe, Regina Busch & Joerg Gruenwald | 2013 |
Baker’s Yeast Beta-Glucan Decreases Episodes of Common Childhood Illness In 1 to 4-Year-Old Children during Cold Season in China. | Group of children were given 75mg BYBG or placebo. The children in BYBG group experienced a reduction in incidence and duration of cold symptoms. | View | Meng F | 2016 |
A Double-Blind, Randomized, Placebo-Controlled Nutritional Study Using an Insoluble Yeast Beta-Glucan to Improve the Immune Defense System | 100 adults were given a placebo or yeast beta-glucan 450mg (the equivalent of 1.8 cans of Mude). The BG group had more subjects without incidences of common cold than the placebo group. Beta-glucan reduced typical cold symptoms compared to placebo. In summary the study demonstrates yeast beta- glucan has a positive effect on the occurrence of the common cold compared to the placebo. | View | Hans-Joachim Graubaum, Regina Busch, Heike Stier, Joerg Gruenwald | 2012 |
Immunity - General
Studies below highlight that yeast beta glucan can have stimulate & strengthen the immune system.
Research
Title | Summary | Link | Authors | Year |
Effects of Low Molecular Weight Yeast β-Glucan on Antioxidant and Immunological Activities in Mice | Mice were given 50mg yeast beta glucan (the equivalent of 1/5 can of Mude). Supplementation with BG improved immune function & exhibited antioxidant activities | View | Na Lei, Mi Wang *, Lifang Zhang, Sui Xiao, Chengzhong Fei, Xiaoyang Wang, Keyu Zhang, Wenli Zheng, Chunmei Wang, Ruile Yang and Feiqun Xue * | 2015 |
β-Glucan successfully stimulated the immune system in different jawed vertebrate species. | Following supplementation with Beta Glucans, 4 different animal species (chicken, pigs, mice, dogs) all displayed a positive response by the immune system. | View | Carlos A.F.de Oliveira, Vaclav Vetvicka, Fábio S.Zanuzzoa | 2019 |
Zebrafish Models for Assessing Immune Booster Functions of Yeast Beta Glucans | Four different samples of beta glucans were found to have a positive effect on the immune system of zebrafish by promoting the formation of cells which attack pathogens and increasing the destruction of pathogens in the body. | XiaoYu Zhu, Bo Xia, Jiao Li, BingYing Lin | 2020 | |
Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise | Subjects were given placebo or 250mg yeast beta glucan (the equivalent of 1 can of Mude). BG supplementation increased number of monocytes (white blood cells) found in the blood post exercise. Study shows BG supplementation increased monocyte (white blood cells), hence increasing the immune response. | View | Brian K McFarlin, Adam S Venable, Katie C Carpenter, Andrea L Henning, Stephan Ogenstad | 2017 |
Effects of beta-glucans on the immune system | Beta Glucans increase host immune defence by enhancing macrophages (cells for destroying pathogens) and natural killer cell function. B-Glucan has been reported to act as immune system activator and cell response modifier. | View | Dalia Akramienė, Anatolijus Kondrotas, Janina Didžiapetrienė 1 , Egidijus Kėvelaitis | 2007 |
Reviews
Title | Summary | Link | Authors | Year |
β‐1,3/1,6‐Glucans and Immunity: State of the Art and Future Directions | Studies show that intake of yeast beta-glucans has an immune strengthening effect. | View | Elena De Marco Castro, Philip C Calder, Helen M Roche | 2020 |
Immune-modulatory effects of dietary Yeast Beta 1,3 1,6 - D-Glucan |
Many studies have shown that when yeast beta glucans are consumed, there is a immune strengthening effect.
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View | Heike Stier, Veronika Ebbeskotte and Joerg Gruenwald | 2014 |
Clinical and physiological perspectives of β-glucans: the past, present, and future |
Many studies show that β-Glucans are believed to stimulate the immune system and thereby have beneficial effects in fighting infectious diseases, such as bacterial, viral, fungal, and parasitic diseases.
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View | Khawaja Muhammad, Imran Bashir and Jae-Suk Choi | 2012 |
Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials |
Many studies show that Glucans improve the general quality of life in improvements in immune status, lowering cholesterol and also the reduction of stress. |
View | Vaclav Vetvicka 1,* , Luca Vannucci 2 , Petr Sima 2 and Josef Richter | 2019 |
Medicinal importance of fungal beta-(1-->3), (1-->6)-glucans |
Many studies have shown that when beta glucans are consumed, the immune system is kicked into action. As a result, they have been effective in treating diseases like cancer, infections, high cholesterol, and diabetes. The exact way the beta glucan works in the body changes depending on the source. |
View | Jiezhong Chen, Robert Seviour | 2007 |
Dietary modulation of immune function by beta-glucans |
Studies have shown that beta glucans can alter the immune response in both animals and humans. After consuming beta glucans, there was an increased resistance to infections. |
View | Julia J.Volman, Julian D.Ramakers, Jogchum Plat | 2008 |
Immune recognition of fungal beta-glucans |
Beta glucans show promise in the treatment of fungal infections. Studies have show that the body, in both animals and humans, can recognise beta glucans following consumption. When they are activated, the immune system is triggered and begins to fight the infection. |
View | Gordon D. Brown, Siamon Gordon | 2005 |
An insight into anti-inflammatory effects of fungal beta-glucans |
Inflammation is the first response of the immune system when we get an infection. Supplementation with Beta Glucans has shown to have anti inflammatory properties and support the immune system. |
View | Bin Duab, Chengyuan Lin, Zhaoxiang Bian, Baojun Xu | 2015 |
Fungal β-Glucans and Mammalian Immunity |
Beta glucans have been shown to have a positive effect against fungal infections. They have shown a positive response against infections and tumours, by modulating the immune system. |
View | Gordon D. Brown, Siamon Gordon | 2003 |
Beta-glucans in higher fungi and their health effects |
Beta Glucans, particularly those from yeast, have been shown to stimulate the immune system. They also have potential anticarcinogenic properties and may increse insulin production. |
View | Otakar Rop, Jiri Mlcek, Tunde Jurikova | 2009 |
Nutraceutical functions of beta-glucans in human nutrition |
Beta glucans offer support to the immune system by binding to immune cells when consumed. They may be beneficial in preventing infectious diseases and gastrointestinal cancer. |
View | Anna Ciecierska, Małgorzata Ewa Drywień, Jadwiga Hamulka, Tomasz Sadkowski | 2019 |
Beta-glucan recognition by the innate immune system |
Beta Glucans are recognised by the immune system and as a result, can have positive effects on human health. This review explores how our body recognises and utilises these beta glucans. |
View | Helen S Goodridge, Andrea J Wolf, David M Underhill | 2009 |
β-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties |
Studies have shown that Beta Glucans can positively influence the immune system when taken alongside vaccines. When taken alone, they were found to regulate the immune system, and when taken in combination with vaccines, they improved their effect. This is thought to be beneficial in anti-cancer treatments. |
View | YimingJin, Pingli Li, Fengshan Wang | 2018 |
Biological Effects of Yeast β-Glucans |
Research showed that Beta glucans are linked to many health benefits. They can aid in inhibiting cancer cell growth and can reduce bacterial infections. They also lower blood cholesterol, improve glucose utilisation and help wound healing. Beta glucans from yeast were found to be the most beneficial. |
View | Vlatka PETRAVIĆ-TOMINAC, Vesna ZECHNER-KRPAN, Slobodan GRBA, Siniša SREČEC, Ines PANJKOTA-KRBAVČIĆ, Lana VIDOVIĆ | 2010 |
The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System |
Studies have shown that supplementation with Beta glucans can aid in regulating the immune system in response to infections, such as fungal infections. They therefore offer potential in the treatment of cancer and infectious disease. This review focuses on how these interactions take place. |
View | Giorgio Camilli, Guillaume Tabouret, Jessica Quintin | 2018 |
Beta-glucans from edible and medicinal mushrooms: Characteristics, physicochemical and biological activities |
Beta Glucans from Mushrooms have been shown to boost the immune system. They also may have antibacterial and antiviral properties. This review focuses on how the beta glucans are extracted from the mushrooms and utilised. |
View | Fengmei Zhu, Bin Du, Zhaoxiang Bian, Baojun Xu | 2015 |
β-(1→3),(1→6)-Glucans: medicinal activities, characterization, biosynthesis and new horizons |
Beta Glucan consumption can boost the immune system to fight against fungal infections. They have antimicrobial and anti-inflammatory effects and can act as a prebiotic. The rate of tumour growth was also found to decrease with beta glucan supplementation. |
View | Nicole Dalonso, Gustavo Henrique Goldman, Regina Maria Miranda Gern | 2015 |
Biomedical Issues of Dietary fiber β-Glucan |
Yeast beta glucan has been found to enhance the immune system to fight against cancer and prevent infections. In addition, susceptibility to post-operative infections may be decreased. When taken alongside chemotherapy or radiation, beta glucans had positive effects on the survival and quality of life of cancer patients. |
View | Soo Young Kim, Hong Ji Song, Yoon Young Lee, Kyung-Hwan Cho, Yong Kyun Roh | 2006 |
The effects of β-glucan on human immune and cancer cells | Most β-glucans enter the proximal small intestine and some are captured by the macrophages. The small BG fragments are released by the macrophages and taken up by other immune cells leading to various immune responses. | View | Godfrey Chi-Fung Chan, Wing Keung Chan and Daniel Man-Yuen Sze | 2009 |
Preparation, characterization, and biological properties of β-glucans | Yeast Beta Glucans shown to have several immune benefiting effects. One study demonstrated that the consumption of oral BG increased the ability of immune cells to consume a bacterial challenge (phagocytosis). Hence helping to fight off bacteria and keep the body healthy. | View | Sandeep Rahar, Gaurav Swami, Navneet Nagpal, Manisha A. Nagpal, and Gagan Shah Singh | 2011 |
Perspective of β-Glucan as Functional Ingredient for Food Industry | β-Glucan is a functional ingredient that possesses numerous health benefits.Beta glucan can produce immune responses through binding with macrophage (cells for destroying pathogens), neutrophils (white blood cells for destroying pathogens) and natural killer cells. | View | Asif Ahmad, Bushra Munir, Muhammad Abrar, Shaukat Bashir, Muhammad Adnan and Tahira Tabassum | 2012 |
Baker's yeast β-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk? | Strenuous exercise is known to weaken the immune system. A group of adults were given 250mg yeast beta glucans (the equivalent of 1 can of Mude) for 10 days. Supplementation with BG increased production of white blood cells which boost immunity. The key findings of the present study demonstrate that BG may have potential to affect immunity following a strenuous exercise session. | View | K C Carpenter, W L Breslin, T Davidson, A Adams, B K McFarlin | 2012 |
Immunity - URTI
Studies below highlight that yeast beta glucan can have beneficial effects in reducing the severity, duration & incidence of UTRI (Upper Respiratory Tract Infections) in subjects.
Reviews
Title | Summary | Link | Authors | Year |
The Immune Benefits of Beta Glucans | Beta Glucans have been shown to play a role in helping the body fend off the common cold, respiratory infections, and more serious diseases such as cancer. They do this by helping to regulate the immune system and stimulating white blood cells. | View | Dr. Gary Gonzalez | 2009 |
Effects of orally administered yeast‐derived beta‐glucans: A review. | Yeast beta glucans support the immune system enhance and can help to fight infections, while also showing anticarcinogenic effects. Adults with susceptible immune systems had a reduction in upper respiratory tract infections following beta glucan supplmentation. | View | Anne Berit C. Samuelsen, Jürgen Schrezenmeir, Svein H. Knutsen | 2013 |
Research
Title | Summary | Link | Authors | Year |
Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects | Regular consumption of 900mg of Beta Glucans (the equivalent of 3.6 cans of Mude) was found to reduce the severity of upper respiratory tract infections (including the common cold & sore throat) during the first week of infection. Mood was improved and blood pressure was decreased. | View | Tanita Dharsono, Karolina Rudnicka, Manfred Wilhelm & Christiane Schoen | 2018 |
Baker's Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women | The consumption of 250mg Beta Glucan (the equivalent of 1 can of Mude) decreased upper respiratory symptoms, such as sore throat & cough in women. Mood and energy levels were increased. | View | Shawn M. Talbott, Julie A. Talbott | 2012 |
Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial | Marathon runners who consumed 250mg Beta Glucan (the equivalent of 1 can of Mude) experienced a decrease in the number of days with symptoms of upper respiratory infections, such as sore throat & cough, and the infection was less severe. The number of workout days missed due to infection was also reduced. | View | Eunice Mah, Valerie N. Kaden, Kathleen M. Kelley & DeAnn J. Liska | 2020 |
Baker's Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise | Following intense exercise, the immune system is weakened and may need additional support. Marathon runners who consumed 250mg Beta Glucan (the equivalent of 1 can of Mude) had reduced cold/flu symptoms following the marathon. Cyclists who consumed 250mg Beta Glucan (the equivalent of 1 can of Mude) experienced increased mucosal immunity. Thus, beta glucans may offset the reduced immune support experienced following intense exercise. | View | Brian K. McFarlin, Katie C. Carpenter, Tiffany Davidson & Meredith A. McFarlin | 2013 |
Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial | Marathon runners were given placebo or 250mg yeast beta glucan (the equivalent of 1 can of Mude). UTRI (Upper Respiratory Tract Infection) severity symptoms were lower for the Beta Glucan group. | View | Eunice Mah, Valerie N. Kaden, Kathleen M. Kelley & DeAnn J. Liska | 2020 |
Yeast-derived β-1,3/1,6 glucan, upper respiratory tract infection and innate immunity in older adults | Group of adults were given placebo or 250mg yeast beta glucan (the equivalent of 1 can of Mude) daily. Daily BG supplementation may protect against UTRI's and reduce the duration of UTRI symptom days. | View | Fuller R, Moore MV, Lewith G, Stuart BL, Ormiston RV, Fisk HL, Noakes PS, Calder PC | 2017 |
Follow-up formula consumption in 3- to 4-year-olds and respiratory infections: an RCT | Group of children were given placebo or FUF (Follow-up Formula) containing Beta-glucan, DHA, & GOS/prebiotic. The BG group had fewer episodes and shorter duration of ARI (acute respiratory infection) fewer missed days of day care and less antibiotic use. The children in BG group also had increased white blood cell suggesting an increase in immunity. | View | Fei Li, Xingming Jin, Bryan Liu, Weihong Zhuang and Deolinda Scalabrin | 2014 |
Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise | Group of marathon runners were given placebo or 250mg capsule of BG (the equivalent of 1 can of Mude) prior to an exercise trial. The BG group was associated with a 37% reduction in the number cold/flu symptom days post marathon compared to the placebo. The study shows that BG may reduce UTRI symptomatic days post exercise. | View | Brian K. McFarlin, Katie C. Carpenter, Tiffany Davidson, & Meredith A. McFarlin | 2013 |
Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections | 100 healthy individuals were given 250mg of yeast beta glucan (the equivalent of 1 can of Mude) or placebo. UTRI symptom severity was monitored. The BG tended to decrease the total number of days with URTI symptoms. Yeast beta glucans may decrease the duration and severity of URTI. | View | K C Carpenter, W L Breslin, T Davidson, A Adams, B K McFarlin | 2012 |
Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women | Healthy women were given placebo or 250mg of BG (the equivalent of 1 can of Mude) daily for 12 weeks. Subjects in the BG group reported fewer upper respiratory symptoms compared to placebo (10% vs 29%), better overall well-being and superior mental/physical energy levels. This data shows that daily dietary supplementation with BG reduces UTRI symptoms and improves mood state in stressed subjects. | View | Shawn M Talbott and Julie A Talbott | 2012 |
Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes | Marathon runners were given placebo or 250mg or 500mg BG (the equivalent of 1 or 2 cans of Mude). Subjects in the treatment groups (250 mg & 500 mg BG) reported significantly fewer URTI symptoms, better overall health and decreased fatigue compared to placebo group. BG may prevent URTI symptoms, and improve overall health and mood following a competitive marathon. | View | Shawn Talbott and Julie Talbott | 2009 |
Randomized Phase II Clinical Trials of Wellmune® for Immune Support During Cold and Flu Season | Healthy adult subjects were given a placebo or 500mg BG (the equivalent of 2 cans of Mude). None of the subjects from the BG group missed work due to colds, they also had a lower fever score compared to the placebo group. This studies suggest that beta glucans can enhance the immune system and reduce risks associate with UTRI. | View | Samantha Feldman, H. Schwartz, D. Kalman, Athena Mayers, Hannah M. Kohrman, R. Clemens, Diane R. Krieger | 2009 |
Effects of an Immunomodulating Supplement on Upper Respiratory Tract Infection Symptoms in Wildland Firefighters: 2001 | Group given a 250mg BG supplement (the equivalent of 1 can of Mude) or placebo for 14 days. There was a trend for the BG trial to demonstrate a lower incidence of URTI symptoms compared to the placebo. A BG supplement may help to suppress symptoms of URTI. | View | Harger-Domitrovich, Stephanie G.; Domitrovich, Joseph W.; Ruby, Brent C. FACSM | 2008 |
Beta 1,3/1,6 Glucan Decreases Upper Respiratory Tract Infection Symptoms and Improves Psychological Well-Being in Moderate to Highly-Stressed Subjects | Moderate to highly stressed subjects were given placebo, 250mg or 500mg BG (the equivalent of 1 or 2 cans of Mude) for 4 weeks. Subjects in both treatment groups (250mg or 500mg a day) reported fewer UTRI symptoms better overall health and increased vigour, enthusiasm & decreased tension. | View | Shawn Talbott and Julie Talbott | 2009 |